CONTENTS
Special
Topic Issue on the Theme of Natural Products
This issue includes reviews and research papers based on lectures
presented at the 23 rd IUPAC International Symposium on the Chemistry
of Natural Products, Florence, Italy, 28 July - 2 August 2002. It was
coordinated by Prof. J. Bull, IUPAC Special Topics
Editor, and Prof. Bruno Botta, Chairman of the Organizing Committee.
> Publication
announced in CI
July 2003 issue
Preface, B.Botta
Part 1: Design and Synthesis of Bioactive Targets
Inspirations from nature. New reactions, new therapeutic leads, and
new drug delivery systems
P. A. Wender, J. L. Baryza, S. E. Brenner, M. O. Clarke, G. G. Gamber,
J. C. Horan, T. C. Jessop, C. Kan, K. Pattabiraman, and T. J. Williams
p. 143 [Abstract] [full
text - pdf 325 KB]
Antiangiogenic heparin-derived heparan sulfate mimics
B. Casu and A. Naggi
p. 157 [Abstract] [full
text - pdf 383 KB]
Semisynthesis and degradation of the tubulin inhibitors epothilone
and tubulysin
G. H�fle, N. Glaser, T. Leibold, U. Karama, F. Sasse, and H. Steinmetz
p. 167 [Abstract] [full
text - pdf 299 KB]
Synthesis of carbohydrate-based antibiotics
C.-H. Wong, M. C. Bryan, P. T. Nyffeler, H. Liu, and E. Chapman
p. 179 [Abstract] [full
text - pdf 253 KB]
DNA minor-groove binders. Design, synthesis and biological evaluation
of ligands structurally related to CC-1065, distamycin, and anthramycin
P. G. Baraldi, M. A. Tabrizi, D. Preti, F. Fruttarolo, B. Avitabile,
A. Bovero, G. Pavani, M. del Carmen Nunez Carretero, and R. Romagnoli
p. 187 [Abstract] [full
text - pdf 198 KB]
HIV-1 integrase inhibitors that block HIV-1 replication in infected
cells. Planning synthetic derivatives from natural products
R. Di Santo, R. Costi, M. Artico, E. Tramontano, P. La Colla, and
A. Pani
p. 195 [Abstract] [full
text - pdf 561 KB]
Part 2: Synthetic Methodology and Total Synthesis
New and old challenges in total synthesis. From concept to practice
S. Hanessian, R. Margarita, A. Hall, S. Johnstone, M. Tremblay,
and L. Parlanti
p. 209 [Abstract] [full
text - pdf 330 KB]
Chemoenzymatic methods for the enantioselective preparation of sesquiterpenoid
natural products from aromatic precursors
M. G. Banwell, A. J. Edwards, G. J. Harfoot, K. A. Jolliffe, M.
D. McLeod, K. J. McRae, S. G. Stewart, and M. V�gtle
p. 223 [Abstract] [full
text - pdf 211 KB]
Total synthesis of (-)-clavukerin A
E. L. Grimm, J.-L. Methot, and M. Shamji
p. 231 [Abstract] [full
text - pdf 171 KB]
Progress in fumagillin synthesis
W. Picoul, O. Bedel, A. Haudrechy, and Y. Langlois
p. 235 [Abstract] [full
text - pdf 484 KB]
Total syntheses of 11-deoxytetrodotoxin and 8,11-dideoxytetrodotoxin
T. Nishikawa, D. Urabe, K. Yoshida, T. Iwabuchi, M. Asai, and M.
Isobe
p. 251 [Abstract] [full
text - pdf 266 KB]
Biomimetic approach toward the stereoselective synthesis of acetogenins
R. V. A. Orru, B. Groenendaal, J. van Heyst, M. Hunting, C. Wesseling,
R. F. Schmitz, S. F. Mayer, and K. Faber
p. 259 [Abstract] [full
text - pdf 203 KB]
Microencapsulated methylrhenium trioxide (MTO)/H2O2 systems for the
oxidation of cardanol derivatives
R. Saladino, E. Mincione, O. A. Attanasi, and P. Filippone
p. 265 [Abstract] [full
text - pdf 227 KB]
Enantioselective synthesis and biological evaluation of a-hydroxylated
lactone lignans
M. Sefkow, M. Raschke, and C. Steiner
p. 273 [Abstract] [full
text - pdf 300 KB]
Stereocontrolled construction of conformationally constrained and
rigid bis(a-amino acid) derivatives
K. Undheim, J. Efskind, and G. B. Hoven
p. 279 [Abstract] [full
text - pdf 414 KB]
Part 3: Structure and Structure Activity of Natural Products
Stereochemical analysis of natural products. Approaches relying on
the combination of NMR spectroscopy and computational methods
R. Riccio, G. Bifulco, P. Cimino, C. Bassarello, and L. Gomez-Paloma
p. 295 [Abstract] [full
text - pdf 338 KB]
Exploitation of proteomics strategies in protein structure-function
studies
G. Marino, P. Pucci, L. Birolo, and M. Ruoppolo
p. 309 [Abstract] [full
text - pdf 737 KB]
Prion protein allotype profiling by mass spectrometry
M. E. Schinin�, B. Maras, F. Cardone, C. Mancone, S. Principe, M.
A. Di Bari, P. Parchi, and M. Pocchiari
p. 317 [Abstract] [full
text - pdf 207 KB]
Toxins from Adriatic blue mussels. A decade of studies
P. Ciminiello, C. Dell'Aversano, E. Fattorusso, M. Forino, and S.
Magno
p. 325 [Abstract] [full
text - pdf 265 KB]
Bioactive macrolides and polyketides from marine dinoflagellates
J. Kobayashi, K. Shimbo, T. Kubota, and M. Tsuda
p. 337 [Abstract] [full
text - pdf 244 KB]
Detection of pharmacologically active natural products using ecology.
Selected examples from Indopacific marine invertebrates and sponge-derived
fungi
P. Proksch, R. Ebel, R. A. Edrada, P. Schupp, W. H. Lin, Sudarsono,
V. Wray, and K. Steube
p. 343 [Abstract] [full
text - pdf 198 KB]
Chemical studies on plant leaf movement controlled by a biological
clock
M. Ueda, T. Sugimoto, Y. Sawai, T. Ohnuki, and S. Yamamura
p. 353 [Abstract] [full
text - pdf 450 KB]
Structural flexibility of hyaluronan oligomers as probed by molecular
modelling
A. Tafi, F. Manetti, F. Corelli, S. Alcaro, and M. Botta
p. 359 [Abstract] [full
text - pdf 224 KB]
Part 4: Biosynthesis and Biotransformations of Natural Products
Functional genomics approach to the study of triterpene biosynthesis
Y. Ebizuka, Y. Katsube, T. Tsutsumi, T. Kushiro, and M. Shibuya
p. 369 [Abstract] [full
text - pdf 208 KB]
Mevalonate-independent methylerythritol phosphate pathway for isoprenoid
biosynthesis. Elucidation and distribution
M. Rohmer
p. 375 [Abstract] [full
text - pdf 266 KB]
Biotransformation of triptonide by cell suspension cultures of Platycodon
grandiflorum
L. Ning, H. Guo, X. Jiang, K. Bi, and D. Guo
p. 389 [Abstract] [full
text - pdf 168 KB]
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis. Discovery
and function of the ispDEFGH genes and their cognate enzymes
F. Rohdich, S. Hecht, A. Bacher, and W. Eisenreich
p. 393 [Abstract] [full
text - pdf 282 KB]
Natural and totally synthetic receptors in the innovative design of
HPLC chiral stationary phases
F. Gasparrini, I. D'Acquarica, D. Misiti, M. Pierini, and C. Villani
p. 407 [Abstract] [full
text - pdf 190 KB]
Combination of enzymatic procedures with multicomponent condensations
R. Ostaszewski, D. E. Portlock, A. Fryszkowska, and K. Jeziorska
p. 413 [Abstract] [full
text - pdf 172 KB]
authors index