Analysis of endocrine active substances in food and the environment
P. T. Holland
Cawthron Institute, 98 Halifax Street E, Nelson, New
Zealand
Abstract: A critical review is made of techniques for analysis
of residues of endocrine active substances (EASs) including sampling,
extraction cleanup and determination based on GC/MS, LC/MS, ELISA, and
bioassays. The growing importance of receptor-based in vitro bioassays
is highlighted for integrated monitoring of environmental levels of
certain classes of EASs and for establishing exposures. Some recent
advances in methods of analysis for each of the key classes of EASs
are summarized including for organochlorines, PCBs, dioxins and dioxin-like
substances, polybrominated diphenyl ethers, phenolic xenoestrogens,
phthalates, organotin compounds, steroidal hormones, and phytoestrogens.
The issues raised in interpreting complementary chemical and bioassay
data at an effects level are briefly discussed.
*Report from a SCOPE/IUPAC project: Implication of
Endocrine Active Substances for Human and Wildlife (J. Miyamoto and
J.Burger, editors). Other reports are published in this issue,
pp. 1617-2615.
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