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Pure Appl. Chem.,
Vol. 70, No. 9, pp. 1617-1631,
1998
Natural and anthropogenic environmental
oestrogens:
the scientific basis for risk assessment
Endocrine disrupters as environmental
signallers: an introduction
P. Preziosi
Department of Pharmacology, Catholic University of the Sacred Heart,
L.go F. Vito, I-00168 Rome, Italy.
E-mail: [email protected]
Abstract: After an historical overview of the endocrine damage to
wildlife caused by environmental xenobiotics (to be distinguished
from natural phytoestrogens), the most important groups of environmental
pollutants endowed with endocrine activity are reviewed showing that
the reproductive system is not the only apparatus affected although
it is the most common target of the xenoestrogens. The mechanisms
of action of putative endocrine disrupters are then discussed. In
this hormonal context, the relationships between the latter compounds
and breast cancer are discussed. The analytical approaches to identify
environmental pollutants with estrogen activity, in particular oestrogens,
are also briefly reviewed. Finally, difficulties in correlating xenobiotic
activity to reduced sperm counts, breast cancer and endocrine changes
are highlighted.
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Page last modified 11 August 1999.
Copyright ©1997, 98, 99 International Union of Pure and Applied
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